The Musée des Confluences is open全年无休,除了星期二和某些节假日。
Note: The original French sentence "Le Musée des Confluences est ouvert toute l'année, sauf le mardi et certains jours fériés." translates more accurately to "The Musée des Confluences is open all year round, except on Tuesdays and certain holidays." However, the provided translation uses a different phrase structure that might be more natural in some English contexts.